Quantitative full time course analysis of nonlinear enzyme cycling kinetics
نویسندگان
چکیده
منابع مشابه
Quantitative full time course analysis of nonlinear enzyme cycling kinetics
Enzyme inhibition due to the reversible binding of reaction products is common and underlies the origins of negative feedback inhibition in many metabolic and signaling pathways. Product inhibition generates non-linearity in steady-state time courses of enzyme activity, which limits the utility of well-established enzymology approaches developed under the assumption of irreversible product rele...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep02658